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2 edition of Modification of PTZ induced seizures in mice by biofrequency ELM fields found in the catalog.

Modification of PTZ induced seizures in mice by biofrequency ELM fields

Michael A. Nolan

Modification of PTZ induced seizures in mice by biofrequency ELM fields

by Michael A. Nolan

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Published by Laurentian University, Department of Psychology in Sudbury, Ont .
Written in English


Edition Notes

Statementby Michael A. Nolan
The Physical Object
Paginationiv, 26, [6] l. :
Number of Pages26
ID Numbers
Open LibraryOL20681720M

  Prediction of PTZ-induced seizures using wavelet-based residual entropy of cortical and subcortical field potentials Abstract: Our proposed algorithm for seizure prediction is based on the principle that seizure build-up is always preceded by constantly changing bursting levels. Similarly PTZ‐induced seizures in naive mice can be blocked by PB, PHT, and VPA (Loscher & Schmidt, ; Kitano et al., ). In the same way, the spontaneous seizures that ensue after pilocarpine‐induced SE can be controlled by all three different AEDs (Leite & Cavalheiro, ). It is, therefore, of interest that the induction of PTZ.

  (a) PTZ induced seizure increases the release of cytochrome-c from mitochondria in prenatal rat hippocampal n blot analyses (2a) of the cytochrome-c in the primary cultured hippocampal neuronal cells at GD from PTZ-induced seizure model during were treated for 20 min with normal media as control (C), media containing mM ethanol (E), media . blocker, in PTZ-induced kindling in mice as well as on the parameters of oxidative stress. The results of the present work revealed that, seizure score and duration are decreased by ivabradine while increased the latency to seizures.

Purpose: To develop a non-invasive method for exploring seizure initiation and propagation in the brain of intact experimental animals. Methods: We have developed and applied a model-independent statistical method - Hierarchical Cluster Analysis (HCA) - for analyzing BOLD-fMRI data following administration of pentylenetetrazol (PTZ) to intact rats. Male Swiss Wistar mice ( g) were i.p. injected with either PTZ or NMDA, placed in a static exposure chamber and observed for 30 minutes during air or solvent exposure ( ppm). The parameters registered were the percentage of animals that presented clonic and/or clonic-tonic (CT) seizures, as well as the latencies to these responses.


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Modification of PTZ induced seizures in mice by biofrequency ELM fields by Michael A. Nolan Download PDF EPUB FB2

Remarkably, in young three-month-old animals, tonic extension of the hindlimbs was observed much more frequently (9/14) than in to month-old mice (2/27).

Young mice are less susceptible to PTZ-induced seizures compared with old mice at all dose groups, which possibly results in a different behavioral by: 8. Methods. Seizures were induced in 7 months albino mice with a single 12 mA intensity of 50 Hz stimulus for s using electroconvulsiometer.

Tonic flexion, tonic extension, clonic convulsion and mortality protection were recorded, 60 minutes after the oral administration of the vehicle (3% Tween 80), Standard (diazepam 3 mg/kg i.p.) and glibenclamide (5 mg/kg).Cited by: 2.

As PTZ seizures do not typically lead to neuropathological injury or spontaneous epilepsy (Wong et al., ; Holmes et al, ), this suggests that the acute phase of seizure-induced mTOR activation is not sufficient to trigger by: The effect of pretreatment with essential oils (EOs) from eight aromatic plants on the seizure latency and severity of pentylenetetrazol- (PTZ-) induced seizures in mice was evaluated.

Weight-dependent doses of Rosmarinus officinalis, Ocimum basilicum, Mentha spicata, Mentha pulegium, Lavandula angustifolia, >Mentha piperita, Origanum dictamnus, and Origanum vulgareCited by: Pentylenetetrazole (PTZ) –induced seizures in mice is an accepted in-vivo model for the screening of antiepileptic drugs.

Seizures are induced by the administration of mg/kg, s.c. PTZ and the mice are then observed for a 60 minute period. Piredda et al. noted that it was impossible to induce supramaximal seizures with in 97% of mice with s.c. administration of PTZ, in contrast to 5 The onset of TE is not the commonly considered endpoint in the anticonvulsant screening using the model.

20 However, it should be noted that PTZ-induced TE ensue a high. Epileptic seizures are associated with increases in hippocampal excitability, but the mechanisms that render the hippocampus hyperexcitable chronically (in epilepsy) or acutely (in status epilepticus) are poorly understood.

Recent evidence suggests that substance P (SP), a peptide that has been implicated in cardiovascular function, inflammatory responses, and nociception, also contributes to. Pentylenetetrazole (PTZ) administration is a commonly preferred behavioral approach used for studying brain ex-citability[13] and for developing AEDs.[14] Chemical kindling seizures induced with PTZ are human absence epilepsy and myclonic, generalized tonic-clonic (primary generalized) seizure models[15] and it is a model for drug resistant.

The present study was conducted to investigate the possible interaction between low doses of nicotine and pentylenetetrazole (PTZ) in vivo and also to evaluate the influence of nicotine on the antiseizure efficacy of topiramate and sodium valproate in the PTZ-induced seizure model in mice.

Graded dose–response study with nicotine showed the CD50 value for nicotine at mg/kg. i.p. Alcohols and glycols ethanol ethylene glycol methanol propylene glycol Anesthetics, local bupivacaine cocaine lidocaine procaine proparacaine tetracaine Anesthetics, general enflurane etomidate isoflurane ketamine methohexital Antibiotics cephalosporins ciprofloxacin gentamicin imipenem/cilastatin isoniazid metronidazole nalidixic acid norfloxacin penicillins Anticonvulsants carbamazepine.

Biphasic effect of sumatriptan on PTZ-induced seizures in mice: Modulation by 5-HT1B/D receptors and NOS/NO pathway.

[Maziar Gooshe, Keyvan Ghasemi, Mohammad Mojtaba Rohani, Abbas Tafakhori, Shayan Amiri, Vajiheh Aghamollaii, Mona Ahmadi, Ahmad Reza Dehpour] PMID As a non-competitive GABA antagonist, PTZ is specifically used in seizure assays as a method of assessing the excitability of the central nervous system and GABA activity.

After administration of an I.P. bolus of PTZ, mice are observed for seizure profile ranking and measurement of latencies to twitches and seizures (clonic/tonic, tonic, clonic). mice to PTZ-induced seizures. To see if the presence of additional copies of Cstb could modify.

the mouse susceptibility to seizure, we challenged control 2n, Ts. Testing Cstb trisomic and tetrasomic mice to PTZ-induced seizures. To test if the presence of additional copies of Cstb increases the susceptibility of the mice to convulsant agents, seizures were induced in 2n, Ts and Tt mice by administration of PTZ at doses of 60, 70, 75, 80 and 90 mg/kg, with different groups of animals being injected for.

MICROANATOMICAL DEFORMATION AFTER PTZ INDUCED SEIZURE IN MICE BRAIN. Yet, certain convulsive behaviors and EEG characteristics were distinct between species. Therefore, a species-specific scale was designed, which included the concomitant EEG characteristic next to the behavioral expressions we observed, in order to establish a user-friendly scoring scale for PTZ-induced seizures in mice.

It is widely accepted that PTZ test is considered as an experimental model of epilepsy, in which the AEDs effective against myoclonic and to a certain extent absence seizures in humans protect.

PTZ (50 mg/kg) and analyzed seizures over 20 min in detail recorded on a videotape. As a result, we found that the pretreatment with L-carnitine clearly suppressed the PTZ-induced seizures even at 10 mmol/kg.

On the other hand, the same dose of D-carnitine, a physiologically inactive form of carnitine, failed to suppress seizures.

DBA/2J mice began expressing spontaneous seizures following the last of eight flurothyl‐induced seizures, suggesting a brief latent period, similar to C57BL/6J mice.

17 There was a tendency for the spontaneous seizures to cluster in DBA/2J mice, and these clusters spanned the recording period. Unlike C57BL/6J mice, in which the spontaneous.

pentylenetetrazol (PTZ) is a GABA A receptor antagonist commonly used as a convulsing drug in experimental studies [25]. The PTZ-induced kindling was first described by Mason and Cooper in rats (). This phenomenon is characterized by an increased suscepti-bility to seizures after repeated injections of PTZ [26].

Read 3 answers by scientists with 8 recommendations from their colleagues to the question asked by Michael K.E. Schaefer on neurons in the brain. Activation of inflammatory cytokines after seizures was first reported by Minami et al, who showed that prolonged seizures induced by injection of pentylenetetrazole (PTZ) in rats caused up-regulation of interleukin-1β (IL-1β), which is a key pro-inflammatory cytokine, in.

The PTZ-induced kindling was first described by Mason and Cooper in rats (). This phenomenon is characterized by an increased susceptibility to seizures after repeated injections of PTZ.

Sato and colleagues have shown that PTZ-induced seizures increase the number of PSA-NCAM positive cells in the hippocampus of kindled rats.